期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 9, 期 5, 页码 1032-1038出版社
LANDES BIOSCIENCE
DOI: 10.4161/hv.23685
关键词
autoimmune disease; experimental autoimmune encephalomyelitis; immune; multiple sclerosis; myelin; neuroantigen; T lymphocytes; therapy; tolerance; vaccine
资金
- National Multiple Sclerosis Society
- National Institute of Neurological Disorders and Stroke [R15-NS075830, R01-NS072150]
Tolerogenic vaccines represent a new class of vaccine designed to re-establish immunological tolerance, restore immune homeostasis, and thereby reverse autoimmune disease. Tolerogenic vaccines induce long-term, antigen-specific, inhibitory memory that blocks pathogenic T cell responses via loss of effector T cells and gain of regulatory T cell function. Substantial advances have been realized in the generation of tolerogenic vaccines that inhibit experimental autoimmune encephalomyelitis in a preclinical setting, and these vaccines may be a prequel of the tolerogenic vaccines that may have therapeutic benefit in Multiple Sclerosis. The purpose here is to provide a snapshot of the current concepts and future prospects of tolerogenic vaccination for Multiple Sclerosis, along with the central challenges to clinical application.
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