期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 8, 期 12, 页码 1817-1828出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/hv.21703
关键词
antibody libraries; immune-diagnostics; phage display; tumor targeting; autoimmune diseases; neurological disorders; transfusion medicine
资金
- European Union within the European Social Fund
One of the most effective molecular diversity techniques is phage display. This technology is based on a direct linkage between phage phenotype and its encapsulated genotype, which leads to presentation of molecule libraries on the phage surface. Phage display is utilized in studying protein-ligand interactions, receptor binding sites and in improving or modifying the affinity of proteins for their binding partners. Generating monoclonal antibodies and improving their affinity, cloning antibodies from unstable hybridoma cells and identifying epitopes, mimotopes and functional or accessible sites from antigens are also important advantages of this technology. Techniques originating from phage display have been applied to transfusion medicine, neurological disorders, mapping vascular addresses and tissue homing of peptides. Phages have been applicable to immunization therapies, which may lead to development of new tools used for treating autoimmune and cancer diseases. This review describes the phage display technology and presents the recent advancements in therapeutic applications of phage display.
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