期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 8, 期 4, 页码 486-490出版社
LANDES BIOSCIENCE
DOI: 10.4161/hv.19229
关键词
MF59; adjuvants; toll like receptor agonists; Men B antigens; Men ACYW
The inclusion of a potent TLR4 immune potentiator to a recombinant antigen vaccine formulation enhances both the magnitude and the breadth of the engendered immune response. One such immune potentiator (TLR4 agonist E6020) was evaluated with recombinant Men B antigens delivered in MF59 sub-micron adjuvant emulsion. The ability of this formulation to enhance serum antibody and bactercidal titers was investigated. The co-delivery of E6020 within MF59 enhanced both the serum and bactericidal titers for Men B antigens and for Men B antigens combined with Men ACWY-CRM conjugate vaccine. The delivery of TLR4 agonist within MF59 emulsion oil droplets leads to a more potent response in comparison to the TLR4 when admixed with MF59 emulsion.
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