期刊
GENOME MEDICINE
卷 6, 期 -, 页码 -出版社
BMC
DOI: 10.1186/gm568
关键词
-
资金
- Japanese Society for the Promotion of Science (JSPS) - DC1 [24.6916]
- Third Term Comprehensive Control Research for Cancer, Ministry of Health, Labour and Welfare [H24-G-004]
- JSPS KAKENHI [23390250, 24591383]
- MEXT KAKENHI [221S0001, 221S0002]
- Grants-in-Aid for Scientific Research [12J06916, 221S0001, 24591383, 23390250, 26293226] Funding Source: KAKEN
Transformation and clonal proliferation of T-cells infected with human T-cell leukemia virus type-I (HTLV-1) cause adult T-cell leukemia. We took advantage of next-generation sequencing technology to develop and internally validate a new methodology for isolating integration sites and estimating the number of cells in each HTLV-1-infected clone (clone size). Initial analysis was performed with DNA samples from infected individuals. We then used appropriate controls with known integration sites and clonality status to confirm the accuracy of our system, which indeed had the least errors among the currently available techniques. Results suggest potential clinical and biological applications of the new method.
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