期刊
GENOME MEDICINE
卷 4, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/gm302
关键词
Side effects; drug repositioning; polypharmacology; mechanism of action
资金
- Spanish Ministerio de Ciencia e Innovacion [BIO2010-22073]
- European Commission [223101]
- ICREA Funding Source: Custom
Side-effects are the unintended consequence of therapeutic treatments, but they can also be seen as valuable read-outs of drug effects in humans; these effects are difficult to infer or predict from pre-clinical models. Indeed, some studies suggest that drugs with similar side-effect profiles may also share therapeutic properties through related mechanisms of action. A recent publication exploits this concept to systematically investigate new indications for already marketed drugs, and presents a strategy to get the most out of the tiny portion of chemicals that have proved to be effective and safe.
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