期刊
G3-GENES GENOMES GENETICS
卷 4, 期 5, 页码 813-821出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.113.010124
关键词
inversions; mimulus; MSG; QTL; recombination
资金
- National Science Foundation [DEB-0841609, IOS-0951254]
- NIH [GM073990]
- University of Kansas Botany Endowment Funds
- Direct For Biological Sciences
- Division Of Environmental Biology [0841609] Funding Source: National Science Foundation
Genotyping-by-sequencing methods have vastly improved the resolution and accuracy of genetic linkage maps by increasing both the number of marker loci as well as the number of individuals genotyped at these loci. Using restriction-associated DNA sequencing, we construct a dense linkage map for a panel of recombinant inbred lines derived from a cross between divergent ecotypes of Mimulus guttatus. We used this map to estimate recombination rate across the genome and to identify quantitative trait loci for the production of several secondary compounds (PPGs) of the phenylpropanoid pathway implicated in defense against herbivores. Levels of different PPGs are correlated across recombinant inbred lines suggesting joint regulation of the phenylpropanoid pathway. However, the three quantitative trait loci identified in this study each act on a distinct PPG. Finally, we map three putative genomic inversions differentiating the two parental populations, including a previously characterized inversion that contributes to life-history differences between the annual/perennial ecotypes.
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