期刊
G3-GENES GENOMES GENETICS
卷 2, 期 9, 页码 987-1002出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.112.003202
关键词
gene regulation; ChIP-Seq; transcription factor binding sites (TFBS); transcription
资金
- National Institutes of Health (USA) [1R01GM084875]
- Canadian Institutes for Health Research
- National Science and Engineering Research Council (NSERC)
- GenomeBC (CanEuCre Project)
- Genome Canada (Pleiades Promoter Project)
- Canadian Institutes of Health Research
- Michael Smith Foundation for Health Research
oPOSSUM-3 is a web-accessible software system for identification of over-represented transcription factor binding sites (TFBS) and TFBS families in either DNA sequences of co-expressed genes or sequences generated from high-throughput methods, such as ChIP-Seq. Validation of the system with known sets of co-regulated genes and published ChIP-Seq data demonstrates the capacity for oPOSSUM-3 to identify mediating transcription factors (TF) for co-regulated genes or co-recovered sequences. oPOSSUM-3 is available at http://opossum.cisreg.ca.
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