期刊
G3-GENES GENOMES GENETICS
卷 2, 期 10, 页码 1197-1205出版社
GENETICS SOC AM
DOI: 10.1534/g3.112.003350
关键词
puf-8; Pumilio; PUF; germline stem cells; proliferative fate; Notch signaling
资金
- National Institutes of Health Nation Center for Research Resources
- Canadian Institutes of Health Research
- Queen Elizabeth II graduate scholarship
- Canadian Institutes of Health Research training grant in Genetics, Child Development Health
Stem cell populations are maintained by keeping a balance between self-renewal (proliferation) and differentiation of dividing stem cells. Within the Caenorhabditis elegans germline, the key regulator maintaining this balance is the canonical Notch signaling pathway, with GLP-1/Notch activity promoting the proliferative fate. We identified the Pumilio homolog, PUF-8, as an inhibitor of the proliferative fate of stem cells in the C. elegans germline. puf-8(0) strongly enhances overproliferation of glp-1 (gf) mutants and partially suppresses underproliferation of a weak glp-1(lf) mutant. The germline tumor that is formed in a puf-8(0); glp-1(gf) double mutant is due to a failure of germ cells to enter meiotic prophase. puf-8 likely inhibits the proliferative fate through negatively regulating GLP-1/Notch signaling or by functioning parallel to it.
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