期刊
G3-GENES GENOMES GENETICS
卷 2, 期 4, 页码 425-427出版社
GENETICS SOC AM
DOI: 10.1534/g3.111.001297
关键词
genome-wide association studies (GWAS); shared data resources; GenPred; simulation method; quantitative trait loci (QTL); pedigrees
资金
- Australian Research Council [LP100100880]
- Genus Pty
- Aviagen LTD
- Pfizer
- Australian Research Council [LP100100880] Funding Source: Australian Research Council
An approach is described for simulating data sequence, genotype, and phenotype data to study genomic selection and genome-wide association studies (GWAS). The simulation method, implemented in a software package called AlphaDrop, can be used to simulate genomic data and phenotypes with flexibility in terms of the historical population structure, recent pedigree structure, distribution of quantitative trait loci effects, and with sequence and single nucleotide polymorphism-phased alleles and genotypes. Ten replicates of a representative scenario used to study genomic selection in livestock were generated and have been made publically available. The simulated data sets were structured to encompass a spectrum of additive quantitative trait loci effect distributions, relationship structures, and single nucleotide polymorphism chip densities.
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