期刊
G3-GENES GENOMES GENETICS
卷 1, 期 6, 页码 505-513出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.111.001164
关键词
epidemiology; genetics; brain infarction; FMNL2
资金
- National Institutes of Health (NIH) Genes, Environment and Health Initiative (GEI) [U01 HG-004436]
- Mid-Atlantic Nutrition and Obesity Research Center [P30 DK-072488]
- Office of Research and Development, Medical Research Service
- Baltimore Geriatrics Research, Education, and Clinical Center of the Department of Veterans Affairs
- GEI [U01 HG-004438-01]
- Division of Adult and Community Health, Centers for Disease Control
- National Institute of Neurological Disorders and Stroke (NINDS)
- NIH Office of Research on Women's Health [R01 NS-45012, U01 NS-069208-01]
- National Institute on Aging, NIH [Z01 AG-000954-06, Z01 AG-000015-50]
- NIH-NINDS [R01 NS-42733, R01 NS-39987, K23 NS-064052, R01 NS-063925, P50 NS-051343]
- American Heart Association/Bugher Foundation Centers for Stroke Prevention Research [0775010N]
- Deane Institute for Integrative Study of Atrial Fibrillation and Stroke
- Keane Stroke Genetics Research Fund
- American Heart Association/Bugher Foundation Centers for Stroke Prevention Research
Ischemic stroke (IS) is among the leading causes of death in Western countries. There is a significant genetic component to IS susceptibility, especially among young adults. To date, research to identify genetic loci predisposing to stroke has met only with limited success. We performed a genome-wide association (GWA) analysis of early-onset IS to identify potential stroke susceptibility loci. The GWA analysis was conducted by genotyping 1 million SNPs in a biracial population of 889 IS cases and 927 controls, ages 15-49 years. Genotypes were imputed using the HapMap3 reference panel to provide 1.4 million SNPs for analysis. Logistic regression models adjusting for age, recruitment stages, and population structure were used to determine the association of IS with individual SNPs. Although no single SNP reached genome-wide significance (P < 5 x 10(-8)), we identified two SNPs in chromosome 2q23.3, rs2304556 (in FMNL2; P = 1.2 x 10(-7)) and rs1986743 (in ARL6IP6; P = 2.7 x 10(-7)), strongly associated with early-onset stroke. These data suggest that a novel locus on human chromosome 2q23.3 may be associated with IS susceptibility among young adults.
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