期刊
G3-GENES GENOMES GENETICS
卷 1, 期 6, 页码 499-503出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.111.001149
关键词
hydroid; cnidarian; invertebrate immunity; recognition
资金
- National Institutes of Health (NIH) [1R5-6AI-079103-01]
- National Science Foundation (NSF) [IOS-0818295]
- NIH [T32-GM-07499]
- Yale Institute for Biospheric Studies (YIBS) Gaylord Donnelley Fellowship
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [818295] Funding Source: National Science Foundation
The Hydractinia allorecognition complex (ARC) was initially identified as a single chromosomal interval using inbred and congenic lines. The production of defined lines necessarily homogenizes genetic background and thus may be expected to obscure the effects of unlinked allorecognition loci should they exist. Here, we report the results of crosses in which inbred lines were out-crossed to wild-type animals in an attempt to identify dominant, codominant, or incompletely dominant modifiers of allorecognition. A claim for the existence of modifiers unlinked to ARC was rejected for three different genetic backgrounds. Estimates of the genetic map distance of ARC in two wild-type haplotypes differed markedly from one another and from that measured in congenic lines. These results suggest that additional allodeterminants exist in the Hydractinia ARC.
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