期刊
BEHAVIOURAL BRAIN RESEARCH
卷 285, 期 -, 页码 60-66出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2014.09.001
关键词
Anterior cingulate cortex; Hippocampus; Lateral entorhinal cortex; Medial prefrontal cortex; Object recognition; Perirhinal cortex central
资金
- McKnight Brain Research Foundation
- NIA [AG003376]
- UF Research Seed Opportunity Fund
Three-dimensional objects are common stimuli that rodents and other animals encounter in the natural world that contribute to the associations that are the hallmark of explicit memory. Thus, the use of 3-dimensional objects for investigating the circuits that support associative and episodic memories has a long history. In rodents, the neural representation of these types of stimuli is a polymodal process and lesion data suggest that the perirhinal cortex, an area of the medial temporal lobe that receives afferent input from all sensory modalities, is particularly important for integrating sensory information across modalities to support object recognition. Not surprisingly, recent data from in vivo electrophysiological recordings have shown that principal cells within the perirhinal cortex are activated at locations of an environment that contain 3-dimensional objects. Interestingly, it appears that neural activity patterns related to object stimuli are ubiquitous across memory circuits and have now been observed in many medial temporal lobe structures as well as in the anterior cingulate cortex. This review summarizes behavioral and neurophysiological data that examine the representation of 3-dimensional objects across brain regions that are involved in memory. (C) 2014 Elsevier B.V. All rights reserved.
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