期刊
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
卷 6, 期 -, 页码 -出版社
FRONTIERS RES FOUND
DOI: 10.3389/fnbeh.2012.00021
关键词
spike frequency adaptation; tonic firing; phasic firing; calcium currents; neuromodulation
资金
- NIH [23945]
- NIMH [64711]
We performed whole-cell recordings from basal forebrain (BF) cholinergic neurons in transgenic mice expressing enhanced green fluorescent protein (eGFP) under the control of the choline acetyltransferase promoter. BF cholinergic neurons can be differentiated into two electrophysiologically identifiable subtypes: early and late firing neurons. Early firing neurons (similar to 70%) are more excitable, show prominent spike frequency adaptation and are more susceptible to depolarization blockade, a phenomenon characterized by complete silencing of the neuron following initial action potentials. Late firing neurons (similar to 30%), albeit being less excitable, could maintain a tonic discharge at low frequencies. In voltage clamp analysis, we have shown that early firing neurons have a higher density of low voltage activated (LVA) calcium currents. These two cholinergic cell populations might be involved in distinct functions: the early firing group being more suitable for phasic changes in cortical acetylcholine release associated with attention while the late firing neurons could support general arousal by maintaining tonic acetylcholine levels.
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