期刊
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/neuro.08.029.2009
关键词
CREB; dorsal striatum; cocaine; morphine; locomotor sensitization; conditioned place preference
资金
- Italian Ministry for the University and Research (MIUR)
- Mariani Foundation for Neurological Research
- NIMH [F31 MH 012955, K08 MH 081190]
- NARSAD
- NATIONAL INSTITUTE OF MENTAL HEALTH [F31MH012955] Funding Source: NIH RePORTER
The striatum participates in multiple forms of behavioral adaptation, including habit formation, other forms of procedural memory, and short- and long-term responses to drugs of abuse. The cyclic-AMP response element binding protein (CREB) family of transcription factors has been implicated in various forms of behavioral plasticity, but its role in the dorsal portion of the striatum-has been little explored. We previously showed that in transgenic mice in which CREB function is inhibited in the dorsal striatum, bidirectional synaptic plasticity and certain forms of long-term procedural memory are impaired. Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine. These findings propose CREB as a positive regulator of dorsal striatum-dependent procedural learning but a negative regulator of drug-related learning.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据