相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial
Stephane Palfi et al.
LANCET (2014)
Memory Enhancement by Targeting Cdk5 Regulation of NR2B
Florian Plattner et al.
NEURON (2014)
Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models
Xuemei Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze
Zhifang Dong et al.
NEUROPHARMACOLOGY (2013)
Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease-Like Pathology and Cognitive Decline in Aged 3xTgAD Mice
Rodrigo Medeiros et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
Eva-Maria Mandelkow et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
ROCK Inhibition Prevents Tau Hyperphosphorylation and p25/CDK5 Increase After Global Cerebral Ischemia
John Fredy Castro-Alvarez et al.
BEHAVIORAL NEUROSCIENCE (2011)
Epidemiology of Alzheimer disease
Christiane Reitz et al.
NATURE REVIEWS NEUROLOGY (2011)
Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
L. Crews et al.
CELL DEATH & DISEASE (2011)
Developing Therapeutic Approaches to Tau, Selected Kinases, and Related Neuronal Protein Targets
Virginia M-Y. Lee et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)
Long-term Preservation of Cone Photoreceptors and Restoration of Cone Function by Gene Therapy in the Guanylate Cyclase-1 Knockout (GC1KO) Mouse
Sanford L. Boye et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)
Aggregation of Detergent-insoluble Tau Is Involved in Neuronal Loss but Not in Synaptic Loss
Tetsuya Kimura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease
Bin Liang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A 24-Residue Peptide (p5), Derived from p35, the Cdk5 Neuronal Activator, Specifically Inhibits Cdk5-p25 Hyperactivity and Tau Hyperphosphorylation
Ya-Li Zheng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice
Diego Piedrahita et al.
JOURNAL OF NEUROSCIENCE (2010)
MECHANISMS OF DISEASE Alzheimer's Disease
Henry W. Querfurth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Validation of a 2-day water maze protocol in mice
Maria Gulinello et al.
BEHAVIOURAL BRAIN RESEARCH (2009)
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
Yipeng Wang et al.
HUMAN MOLECULAR GENETICS (2009)
Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice
Ryan L. Boudreau et al.
MOLECULAR THERAPY (2009)
Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs
Ryan L. Boudreau et al.
RNA (2008)
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice
Lani K. Clinton et al.
NEUROBIOLOGY OF DISEASE (2007)
Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation
Ammar H. Hawasli et al.
NATURE NEUROSCIENCE (2007)
Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats
Yi Wen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration
Jian-Zhi Wang et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2007)
Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC
Krystof S. Bankiewicz et al.
MOLECULAR THERAPY (2006)
Lessons from Nature: microRNA-based shRNA libraries
Kenneth Chang et al.
NATURE METHODS (2006)
Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice
AKY Fu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
LM Billings et al.
NEURON (2005)
A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons
YL Zheng et al.
EMBO JOURNAL (2005)
Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus
P Cardona-Gomez et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2004)
Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick type C mice
M Zhang et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
JC Cruz et al.
NEURON (2003)
Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
J Wang et al.
NATURE NEUROSCIENCE (2003)
Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes
MA Kurt et al.
NEUROBIOLOGY OF DISEASE (2003)
Triple-transgenic model of Alzheimer's disease with plaques and tangles:: Intracellular Aβ and synaptic dysfunction
S Oddo et al.
NEURON (2003)
Cdk5 is a key factor in tau aggregation and tangle formation in vivo
W Noble et al.
NEURON (2003)
Insect cells as a factory to produce adeno-associated virus type 2 vectors
M Urabe et al.
HUMAN GENE THERAPY (2002)
tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau
M DeTure et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells
YL Zheng et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
JC Augustinack et al.
ACTA NEUROPATHOLOGICA (2002)
Neurotoxicity induces cleavage of p35 to p25 by calpain
MS Lee et al.
NATURE (2000)
分享论文
