期刊
BEHAVIOURAL BRAIN RESEARCH
卷 281, 期 -, 页码 32-42出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2014.12.012
关键词
Alzheimer's disease; Hesperidin; Transgenic mouse model; Cerebral amyloidosis; Behavioral deficit; Neuro-inflammation
资金
- Chinese government scholarship from the China Scholarship Council (CSC)
- National Natural Science Foundation of China [61102145, 61374093]
- Research Project of Chongqing ST Committee [cstc2013jcyjA40014]
In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in Alzheimer's disease and its animal models. Hesperidin, a flavanone glycoside found abundantly in citrus fruits, was orally given (100 mg/kg body weight) to 5-month-old transgenic APP/PS1 mice, a mouse model of cerebral amyloidosis for Alzheimer's disease. After a relatively short-term treatment of 10 days, hesperidin significantly restored deficits in non-cognitive nesting ability and social interaction. Further immunohistochemical analysis showed significantly attenuated beta-amyloid deposition, plaque associated APP expression, microglial activation and TGF-beta immunoreactivity in brains of APP/PSI mice, which suggests that ameliorated behavioral impairments might be attributable to reduced Ap deposition and attenuated neuro-inflammatory reaction. Additionally, efficient anti-inflammatory effects of hesperidin were confirmed in vitro. Our findings suggest that hesperidin might be a potential candidate for the treatment of AD or even other neurodegenerative diseases. (C) 2014 Elsevier B.V. All rights reserved.
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