期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2013.00027
关键词
aging; cognitive decline; IGF-1; vasculature
资金
- American Federation for Aging Research
- Oklahoma Center for the Advancement of Science and Technology
- American Heart Association
- NIH [AG031085, AT006526, AG038747, NS056218, P01AG11370]
- Ellison Medical Foundation
Insulin-like growth facto-1 (IGF-1) is an imprtant anabolic hormone that decreases with age. In the past two decades, extensive research has determined that the reduction in IGF-1 is an important component of the age-related decline in cognitive function in multiple species including humans. Deficiency in circulating IGF-1 results in impairment in processing speed and deficiencies in both spatial and working memory. Replacement of IGF-1 or factors that increase IGF-1 to told animals and humans reverses many of these cognitive deficits. Despite the overwhelming evidence of IGF-1 as an important neurotrophic agent, the specific mechanism through which IGF-1 as an important neurotrophic agent, the specific mechanisms through which IGF-1 acts have remained elusive. Recent evidence indicates that IGF-1 is both produced by and has important actions on the cerebrovasculature as well as neurons and glia. Nevertheless, the specific regulation and actions of brain- and vascular-derived IGF-1 is poorly understood. The diverse effects of IGF-1 discoverd thus far reveal a complex endocrine and paracrine system essential for integrating many of the functions necessary for brain health. Identification of the mechanism of IGF-1 actions will undoubtly provide critical insight into regulation of brain function in general and the causes of cognitive decline with age.
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