期刊
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
卷 9, 期 2, 页码 191-196出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/17474124.2014.950228
关键词
Crohn's disease; genetics; genome-wide association studies; IL-10R mutations; inflammatory bowel disease; ulcerative colitis; very early-onset IBD
Clinical observations and epidemiological studies have highlighted some important differences in disease course and phenotypes between pediatric inflammatory bowel disease (IBD) and adult-onset IBD. Also from a therapeutic angle, the approach to young-onset IBD is different with a more rapid introduction of azathioprine and a high threshold for long and systemic steroid use, which may affect bone mineral density and growth. The observed clinical differences have been an area of scientific research and genetic studies have been the focus of attention. Specific candidate gene studies as well as genome-wide association studies have been performed in pediatric IBD. With the exception of very early-onset IBD occurring before the age of 2 years; no overt differences in genetic susceptibility have been identified. In contrast, very early-onset IBD seems in particular to be a genetic disease with defects in the IL10 signaling pathway being the principal example. This review aims to answer some straightforward questions arising in this topic by giving concise information.
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