期刊
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
卷 7, 期 4, 页码 365-385出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/EGH.13.21
关键词
autoimmune hepatitis; cholestasis; ethnic background; genetic predispositions; non-white patients; regional differences
Autoimmune hepatitis has diverse clinical phenotypes and outcomes in ethnic groups within a country and between countries, and these differences may reflect genetic predispositions, indigenous etiological agents, pharmacogenomic mechanisms and socioeconomic reasons. In the USA, African-American patients have cirrhosis more commonly, treatment failure more frequently and higher mortality than white American patients. Survival is poorest in Asian-American patients. Autoimmune hepatitis in other countries is frequently associated with genetic predispositions that may favor susceptibility to indigenous etiological agents. Cholestatic features influence treatment response; acute-on-chronic liver disease increases mortality and socioeconomic and cultural factors affect prognosis. Ethnic-based deviations from classical phenotypes and the frequency of late-stage disease can complicate the diagnosis and management of autoimmune hepatitis in non-white populations.
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