期刊
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
卷 8, 期 1, 页码 111-117出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/17474124.2014.844648
关键词
epidermal growth factor receptor; gastric cancer; prognosis; target therapy
资金
- National Natural Scientific Foundation of China [81100714, 81171923]
- Foundation of Shaanxi Province Science and Technology research [2012KJXX-20]
- Top Ph.D. Foundation of China [201075]
Despite tremendous efforts to reduce deaths due to gastric cancer, it represents the second leading cause of cancer-related deaths worldwide. EGF receptor (EGFR) plays important roles in gastric carcinogenesis by regulation of cell cycle, angiogenesis and apoptosis. This review evaluates the functions, mechanisms and clinical uses of EGFR in gastric cancer. Although EGFR targeted single therapy shows limited effect, the combination of EGFR targeted agents with traditional chemotherapy regimens may bring about important progress in cancer therapy. More clinical trials should be performed to clarify both the prognostic and therapeutic value of EGFR in gastric cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据