期刊
BEHAVIOURAL BRAIN RESEARCH
卷 293, 期 -, 页码 241-251出版社
ELSEVIER
DOI: 10.1016/j.bbr.2015.06.043
关键词
Schizophrenia; Subtype; Bipolar disorder; Major depressive disorder; Gene; Association
资金
- Natural Science Foundation of Shandong Province [ZR2013HM078, ZR2010HQ051, Z2008C11, Z2004C10]
- Shandong Province Science and Technology Development Plan [2011GSF11821]
- National High-tech R&D Program of China (863 Program) [2002AA223021]
- National Natural Science Foundation of China [30770780, 30440042]
- Ministry of Human Resources and Social Security of China [2009.416]
- Department of Science & Technology of Shandong Province [2008GG27C01011-8]
- National Bureau of Foreign Experts Affairs [CG2006370002]
- Shandong Bureau of Foreign Experts Affairs (Shandong Academy of Medical Sciences) [2012-25, 2009-15, L20063700407]
Convergent evidence from genetics, symptology and psychopharmacology imply that there are intrinsic connection between schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD). Also, any two or even three of these disorders could co-existe in some families. A total of 47,144 single nucleotide polymorphism (SNPs) on chromosome 7 were genotyped by Affymetrix Genome-Wide Human SNP array 6.0 on 119 SCZ, 253 BPD (type-I), 177 MDD, and 1000 controls. Associated SNP loci were comprehensively revealed and outstanding susceptibility genes were identified including CNTNAP2. a neurexin family gene. Unexpectedly, flanking genes for up to 94.74 % of of the associated SNPs were replicated (P <= 9.9 E-8) in an enlarged cohort of 986 SCZ patients. Considering other convergent evidence, our results further implicate that BPD and MDD are subtypes of SCZ. (C) 2015 Elsevier B.V. All rights reserved.
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