期刊
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
卷 13, 期 9, 页码 786-792出版社
OXFORD UNIV PRESS
DOI: 10.1093/ehjci/jes079
关键词
Computed tomography; Coronary calcification; PET; Myocardial perfusion imaging; Attenuation correction
资金
- GE Healthcare
- Lantheus Medical Imaging
- MDS Nordion
- DRAXimage
- Vered-Beanlands Cardiology Endowed Research Fellowship
- Division of Cardiology, University of Ottawa Heart Institute
- Molecular Function and Imaging (MFI) Program (HSFO program) [PRG6242]
- Heart and Stroke Foundation of Ontario (HSFO)
- CIHR New Investigator Award [MSH-83718]
- Ontario Research Fund [RE02-038]
- Canada Foundation for Innovation [11966]
- TeraRecon Inc.
Aims Cardiac computed tomography (CT) measured coronary artery calcium (CAC-CT) is a well-validated and accurate tool for estimating atherosclerotic burden and prognosis. Computed tomography attenuation correction (ACCT) obtained during cardiac positron emission tomography (PET) has been used to visually estimate CAC; however, quantification using a non-gated ACCT images has not been described. We sought to understand the relationship between CAC measured using cardiac computed tomography (CT) and CAC using ACCT images obtained during cardiac PET perfusion imaging. Methods and results Patients with both CAC-CT and cardiac PET within 6 months of each other were identified. CAC-CT images were scored using the Agatston scoring method, while ACCT images were scored using different attenuation thresholds for calcium. CAC-CT and ACCT scores were compared. Between August 2007 and October 2010, 91 patients were included in the analysis. Interobsever reliability was excellent at all thresholds of detection tested. Pearson correlation was strongest between CAC-CT and ACCT at 50 HU threshold of detection (ACCT(50)). Implementing CAC categories (0, 1-100, 101-400, >400), there was a high degree of agreement between observers as well as between CAC-CT and ACCT(50). Correlation was best for lower CAC scores; however, as CAC-CT increased, ACCT(50) underestimated CAC. Conclusion Keywords Quantifying CAC using ACCT images appears to be feasible and accurate. In a single cardiac PET examination, information regarding perfusion, LV function, flow quantification, and CAC can be obtained without additional radiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据