期刊
BEHAVIOURAL BRAIN RESEARCH
卷 278, 期 -, 页码 286-292出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2014.05.027
关键词
Depression, Major depressive disorder, MDD; Chronic unpredictable mild stress, CUMS; Prefrontal cortex, PFC; Metabonomic, metabolomic
资金
- National Basic Research Program of China (973 Program) [2009CB918300]
- National Natural Science Foundation of China [31300881, 31300917]
Major depressive disorder (MDD) is a debilitating mood disorder. However, the molecular mechanism(s) underlying depression remain largely unknown. Here, we applied a GC-MS-based metabonomic approach in the chronic unpredictable mild stress (CUMS) model, a well-established rodent model of depression, to investigate significant metabolic changes in the rat prefrontal cortex (PFC). Multivariate statistical analysis - including principal component analysis, partial least squares-discriminate analysis, and pair-wise orthogonal projections to latent structures discriminant - was applied to identify differential PFC metabolites between CUMS rats and healthy controls. As compared to healthy control rats, CUMS rats were characterized by lower levels of isoleucine and glycerol in combination with higher levels of N-acetylaspartate and beta-alanine. These findings should provide insight into the pathophysiological mechanism(s) underlying MDD and preliminary leads relevant to diagnostic biomarker discovery for depression. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据