期刊
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
卷 7, 期 -, 页码 65-75出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2013.11.003
关键词
Adolescence; Aerobic exercise; White matter; Diffusion tensor imaging; Tractography
资金
- National Institutes of Health [F31AA019866, R01 AA017664, K08 NS052147, R01 MH087563, R01 HD053893, F30 AA020431, T32 GM008042]
- Dana Foundation
- Oregon Clinical and Translational Research Institute
- OHSU Tartar Trust Research Fellowship
- American Psychological Association Science Directorate's Dissertation Research Award
- ARCS Foundation, Inc. Portland Chapter
Exercise has been shown to have positive effects on the brain and behavior throughout various stages of the lifespan. However, little is known about the impact of exercise on neurodevelopment during the adolescent years, particularly with regard to white matter microstructure, as assessed by diffusion tensor imaging (DTI). Both tract-based spatial statistics (TBSS) and tractography-based along-tract statistics were utilized to examine the relationship between white matter microstructure and aerobic exercise in adolescent males, ages 15-18. Furthermore, we examined the data by both (1) grouping individuals based on aerobic fitness self-reports (high fit (HF) vs. low fit (LF)), and (2) using VO2 peak as a continuous variable across the entire sample. Results showed that HF youth had an overall higher number of streamline counts compared to LF peers, which was driven by group differences in corticospinal tract (CST) and anterior corpus callosum (Fminor). In addition, VO2 peak was negatively related to FA in the left CST. Together, these results suggest that aerobic fitness relates to white matter connectivity and microstructure in tracts carrying frontal and motor fibers during adolescence. Furthermore, the current study highlights the importance of considering the environmental factor of aerobic exercise when examining adolescent brain development. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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