期刊
CURRENT STEM CELL RESEARCH & THERAPY
卷 9, 期 3, 页码 162-173出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X09666140213150218
关键词
Application; cell sheet technology; co-culture; micro-printing; periodontal regeneration; tissue engineering
资金
- Shanghai Municipal Health Bureau of Young Scientific Research Project [20124Y049]
- Tongji University Young Talents Supporting Program [1501-219-058]
Tissue engineering has yielded several successes in early clinical trials of regenerative medicine with grafting therapeutic cells seeded into biodegradable scaffolds. However this conventional cell delivery method has limited the field's progress. In recent decades, we have developed a novel cell transferring method, cell sheet technology that allows for controlled attachment and detachment of cells via simple temperature variations of a surface-intelligent temperature-responsive polymer: poly (N-isopropylacry lamide). It has been widely applied to create functional tissue sheets with cells derived from various tissues to treat a wide range of diseases. Periodontal cell sheets non-invasively harvested from temperature-responsive culture surfaces have been successfully manufactured, resulting in communicative multilayered constructs. Transplantation of cell sheets onto periodontal defects has improved bone and tissue regeneration in animal models and humans and shows low immunogenicity. In this review, we summarize the recent advances of techniques in cell sheet engineering and its application for periodontal regeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据