期刊
CURRENT STEM CELL RESEARCH & THERAPY
卷 8, 期 4, 页码 313-323出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X11308040007
关键词
Fluid shear stress (FSS); matrix stiffness; mechanotransduction; mesenchymal stem cells (MSCs); stem cells fate; three dimensions (3D)
资金
- National Natural Science Foundation of China [11172338, 11032012]
- Program for New Century Excellent Talents in University [NCET-10-0879]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
- Fundamental Research Funds for the Central Universities [CDJZR 12238801, CDJXS 12230006]
- Chongqing University
Stem cells have the ability to self-renew and to differentiate into multiple mature cell types during early life and growth. Stem cells adhesion, proliferation, migration and differentiation are affected by biochemical, mechanical and physical surface properties of the surrounding matrix in which stem cells reside and stem cells can sensitively feel and respond to the microenvironment of this matrix. More and more researches have proven that three dimensional (3D) culture can reduce the gap between cell culture and physiological environment where cells always live in vivo. This review summarized recent findings on the studies of matrix mechanics that control stem cells (primarily mesenchymal stem cells (MSCs)) fate in 3D environment, including matrix stiffness and extracellular matrix (ECM) stiffness. Considering the exchange of oxygen and nutrients in 3D culture, the effect of fluid shear stress (FSS) on fate decision of stem cells was also discussed in detail. Further, the difference of MSCs response to matrix stiffness between two dimensional (2D) and 3D conditions was compared. Finally, the mechanism of mechanotransduction of stem cells activated by matrix mechanics and FSS in 3D culture was briefly pointed out.
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