期刊
CURRENT OPINION IN VIROLOGY
卷 33, 期 -, 页码 106-112出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2018.08.001
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资金
- Wellcome Trust (UK) [103068/Z/13/Z]
- National Institutes of Health [R03 AI131072]
- Indiana University Start-Up Funding
- Lawrence M Blatt Endowment
- Wellcome Trust [103068/Z/13/Z] Funding Source: Wellcome Trust
Segmented double-stranded (ds)RNA viruses share remarkable similarities in their replication strategy and capsid structure. During virus replication, positive-sense single-stranded (+)RNAs are packaged into procapsids, where they serve as templates for dsRNA synthesis, forming progeny particles containing a complete equimolar set of genome segments. How the +RNAs are recognized and stoichiometrically packaged remains uncertain. Whereas bacteriophages of the Cystoviridae family rely on specific RNA-protein interactions to select appropriate +RNAs for packaging, viruses of the Reoviridae instead rely on specific intermolecular interactions between +RNAs that guide multi-segmented genome assembly. While these families use distinct mechanisms to direct +RNA packaging, both yield progeny particles with a complete set of genomic dsRNAs.
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