期刊
CURRENT OPINION IN VIROLOGY
卷 7, 期 -, 页码 11-18出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2014.03.005
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资金
- University of Saskatchewan
- National Science and Engineering Research Foundation [RGPIN-342475]
- Saskatchewan Health Research Foundation [RAPID 1927]
- McGill University
MicroRNAs (miRNAs) are small non-coding RNAs that function as part of RNA-induced silencing complexes that repress the expression of target genes. Over the past few years, miRNAs have been found to mediate complex regulation of a wide variety of mammalian viral infections, including Hepatitis C virus (HCV) infection. Here, we focus on a highly abundant, liver-specific miRNA, miR-122. In a unique and unusual interaction, miR-122 binds to two sites in the 5' untranslated region (UTR) of the HCV genome and promotes viral RNA accumulation. We will discuss what has been learned about this important interaction to date, provide insights into how miR-122 is able to modulate HCV RNA accumulation, and how miR-122 might be exploited for antiviral intervention.
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