期刊
CURRENT OPINION IN VIROLOGY
卷 9, 期 -, 页码 154-161出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2014.10.001
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资金
- US National Institute of Health Grant [U19-AI10958]
Most adults remain chronically infected with HHV-6 after resolution of a primary infection in childhood, with the latent virus held in check by the immune system. latrogenic immunosuppression following solid organ transplantation (SOT) or hematopoetic stem cell transplantation (HSCT) can allow latent viruses to reactivate. HHV-6 reactivation has been associated with increased morbidity, graft rejection, and neurological complications post-transplantation. Recent work has identified HHV-6 antigens that are targeted by the CD4+ and CD8+ T cell response in chronically infected adults. T cell populations recognizing these targets can be expanded in vitro and are being developed for use in autologous immunotherapy to control post-transplantation HHV-6 reaction.
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