期刊
CURRENT OPINION IN VIROLOGY
卷 3, 期 4, 页码 468-474出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2013.05.005
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资金
- Wellcome Trust [090382, 25092]
- Medical Research Council UK [G0902266]
- comprehensive Biomedical Research Centre (cBRC) at Imperial College NHS Healthcare Trust
- MRC [G0902266] Funding Source: UKRI
- Asthma UK [S06/001] Funding Source: researchfish
- Medical Research Council [G0902266, G1000758] Funding Source: researchfish
Respiratory syncytial virus (RSV) is the most important cause of infantile bronchiolitis and a major pathogen in elderly and immunosuppressed persons. Although RSV shows limited antigenic diversity, repeated infections occur throughout life. Vaccine development has been delayed by poor immunogenicity, production issues and the fear of causing enhanced disease. T cells assist in viral clearance, but immune regulation serves to limit these responses and to prevent the exaggerated inflammatory response to RSV infection seen in children with bronchiolitis. Severe RSV disease can therefore be regarded as a dysregulated response to an otherwise trivial infection. Further insights into the role of T cells (including Th17) are needed to enable the rational design of safe, effective vaccines and novel treatments.
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