期刊
CURRENT OPINION IN VIROLOGY
卷 2, 期 2, 页码 160-167出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2012.03.003
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资金
- Japan Initiative for Global Research Network on Infectious Diseases from the Ministries of Education, Culture, Sports, Science, and Technology of Japan
- Health, Labor, and Welfare of Japan
- Ministry of Health
- ERATO (Japan Science and Technology Agency)
- National Institute of Allergy and Infectious Diseases Public health Service Research grants
Influenza A virus infection begins with the binding of the hemagglutinin (HA) glycoprotein to sialic acid-containing receptors on the surface of the target cell. Avian influenza viruses, including avian H5N1, H7, and H9N2 viruses, can occasionally cross the species barrier and infect humans; however, these viruses do not spread efficiently from person to person, perhaps, partly, owing to differences in the receptor-binding specificities of human and avian influenza viruses. The HAs of avian influenza viruses must adapt to receptors in humans to acquire efficient human-to-human transmissibility. In this review, we discuss the receptor binding specificity of influenza A viruses and its role in interspecies transmission.
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