期刊
CURRENT HEMATOLOGIC MALIGNANCY REPORTS
卷 8, 期 1, 页码 28-36出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11899-012-0152-z
关键词
CML; Epigenetics; microRNA; Tyrosine kinase inhibitors
资金
- IGA MZCR [NT11555]
- UNCE [204021]
- Operational Program Research and Development for Innovations [CZ.1.05/1.1.00/02.0109]
- [GACR P305/12/1033]
- [FR-TI2/509]
- [PRVOUK-P24/LF1/3]
- [SVV-2012-264507]
The efficacy of therapeutic modalities in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms. This review focuses on epigenetic mechanisms involved in the pathogenesis of CML and in resistance of tumor cells to tyrosine kinase inhibitors leading to the leukemic clone escape and propagation. Regulatory events at the levels of gene regulation by transcription factors and microRNAs are discussed in the context of CML pathogenesis and therapeutic modalities.
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