期刊
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
卷 4, 期 4, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a019299
关键词
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资金
- National Institutes of Health (NIH) [AI014209, AI085548, AI096945, AI102311]
- U.S. Army Medical Research and Materiel Command [W81XWH-13-C-0103]
- Office of Congressionally Directed Medical Research Programs
- Joint Warfighter Medical Research Program
Early diagnosis of fungal infection is critical to effective treatment. There are many impediments to diagnosis such as a diminishing number of clinical mycologists, cost, time to result, and requirements for sensitivity and specificity. In addition, fungal diagnostics must meet the contrasting needs presented by the increasing diversity of fungi found in association with the use of immunosuppressive agents in countries with high levels of medical care and the need for diagnostics in resource-limited countries where large numbers of opportunistic infections occur in patients with AIDS. Traditional approaches to diagnosis include direct microscopic examination of clinical samples, histopathology, culture, and serology. Emerging technologies include molecular diagnostics and antigen detection in clinical samples. Innovative new technologies that use molecular and immunoassay platforms have the potential to meet the needs of both resource-rich and resource-limited clinical environments.
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