期刊
CONTACT LENS & ANTERIOR EYE
卷 36, 期 6, 页码 272-280出版社
ELSEVIER
DOI: 10.1016/j.clae.2013.07.008
关键词
Dry eye; Keratoconjunctivitis sicca; Artificial tears; Rose bengal; Lissamine green
Purpose: To review the use of ophthalmic rose bengal to assess the ocular surface, especially considering the grading scales used. Methods: A literature search was undertaken to identify reports where either rose bengal or lissamine green had been used as a 'vital' stain, with a special interest in identifying studies that provided data before and after treatment for dry eye and also considered the mechanism of action of these two chemicals. Results: Between 1985 and 2006, numerous clinical studies used a consistent grading scheme (that attributed to Van Bijsterveld) to assess the outcome of artificial tear treatments on dry eye patients. With such consistency, including the adoption of a treatment period of 1 month, comparisons can be made to indicate the efficacy of rose bengal staining to assess reduction in ocular surface desiccation. However, in the following years, several alternative grading schemes have been used for both rose bengal and lissamine green and assessment periods have been variable so making inter-study comparisons considerably more difficult to undertake. An attribute of rose bengal appears to be its ability to stain the nuclei of cells, but whether this also occurs for lissamine green is unclear. Conclusions: Ophthalmic rose bengal has-been successfully adopted for use to-assess the ocular surface over many years as a vital stain. More research is needed to assess whether lissamine green ocular surface staining can simply be substituted for rose bengal in evaluation of dry eye treatments. (C) 2013 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据