期刊
CHEMPLUSCHEM
卷 79, 期 9, 页码 1284-1293出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201402031
关键词
chelates; copper; density functional calculations; ligand design; radiopharmaceuticals
资金
- French Ministry of Education
- Centre National de la Recherche Scientifique (CNRS)
- French National Agency for Research [ANR-11-EQPX-0004]
- Region Pays de la Loire (NUCSAN project)
A highly stable copper(I) complex was obtained starting from a copper(II) salt. This compound was characterized by a combination of several analytical techniques (UV/Vis spectroscopy, energy-dispersive X-ray spectroscopy, electrochemistry, and X-ray photoelectron spectroscopy) and was shown to present an N4Cu structure. These results were confirmed by a density functional calculations study of the binding energy and the electronic structure of model ligand and copper complexes. Preliminary tests of complexation showed a high ability of the corresponding ligand to chelate Cu-64 in very diluted medium, which is of interest for developing new positron emission tomography imaging agents. The stability and the kinetic inertness of the complex are promising. In particular, it displayed good redox stability, which is important because in vivo reduction or oxidation of the copper of Cu complexes can lead to demetalation. The rapid microwave-assisted strategy used to synthesize the ligand was applied to the synthesis of more than ten ligands. One of these was functionalized by an amino group to form a bifunctional chelate for a future bioconjugation for applications in nuclear medicine.
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