期刊
CHEMPLUSCHEM
卷 77, 期 9, 页码 817-831出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201200099
关键词
bimodal pore system; drug delivery; ibuprofen; nanoparticles; silica
资金
- Ministerio de Educacion y Ciencia [MAT2009-14564-C04-04]
- Generalitat Valenciana [PROMETEO/2009/108]
- Plan Nacional de Materiales
- VLC/CAMPUS (MCIs Sensores y Tecnicas Analiticas Rapidas and Medicina Regenerativa)
The capability of UVM-7 silicas to work as supports for drug storage and delivery is investigated using ibuprofen as a model. UVM-7 silicas are surfactant-assisted synthesised mesoporous materials displaying a characteristic bimodal pore architecture related to their nanoparticulate texture. Strict control of the drug-charge protocol allows the achievement of high ibuprofen loads, not only because of the availability of intra-nanoparticle mesopores and large textural voids, but also owing to the decrease in pore-blocking effects (with regard to related unimodal mesoporous materials such as MCM-41) achieved through the shortening of the mesopore length. The UVM-7/ibuprofen nanocomposites are characterised using XRD, TEM and N2 adsorption/desorption isotherms, and the drug-delivery processes are monitored by spectrometric techniques. The bimodal porosity results in two-stage drug-delivery processes, which are analysed through kinetic models.
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