期刊
CELL REPORTS
卷 24, 期 9, 页码 2392-2403出版社
CELL PRESS
DOI: 10.1016/j.celrep.2018.07.089
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资金
- Fundacion Bancaria Caja de Ahorros de Asturias
- European Union (ERC-2016-ADG, DeAge)
- Ministerio de Economia y Competitividad [MINECO/FEDER: SAF2014-52413-R, SAF2017-87655-R, MINECO/FEDER: SAF2015-64157-R, MINECO/FEDER: BFU2015-68539]
- Instituto de Salud Carlos III (RTICC)
- Progeria Research Foundation [PRF2016-66]
- EDP Foundation
- Gobierno del Principado de Asturias
- Ramon y Cajal Program [RYC-2013-12751]
- BBVA Foundation [BBM_BIO_3105]
- Ligue contre le Cancer (equipe labelisee)
- Agence National de la Recherche (ANR) - Projets Blancs
- ANR
- ERA-Net for Research on Rare Diseases
- Association pour la Recherche sur le Cancer (ARC)
- Canceropole Ile-de-France
- Institut National du Cancer (INCa)
- Institut Universitaire de France
- Fondation pour la Recherche Medicale (FRM)
- European Commission (ArtForce)
- European Research Council (ERC)
- LeDucq Foundation
- LabEx Immuno-Oncology
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
Dietary intervention constitutes a feasible approach for modulating metabolism and improving the health span and lifespan. Methionine restriction (MR) delays the appearance of age-related diseases and increases longevity in normal mice. However, the effect of MR on premature aging remains to be elucidated. Here, we describe that MR extends lifespan in two different mouse models of Hutchinson-Gilford progeria syndrome (HGPS) by reversing the transcriptome alterations in inflammation and DNA-damage response genes present in this condition. Further, MR improves the lipid profile and changes bile acid levels and conjugation, both in wild-type and in progeroid mice. Notably, treatment with cholic acid improves the health span and lifespan in vivo. These results suggest the existence of a metabolic pathway involved in the longevity extension achieved by MR and support the possibility of dietary interventions for treating progeria.
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