期刊
CELL REPORTS
卷 24, 期 8, 页码 2042-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2018.07.054
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资金
- CRCNS grant
- ANR [14-NEUC-0001-01, 13-BSV4-0014-02]
- NIH [EY-020592]
- CONICET [PIP 112 201301 00256]
The connectivity principles underlying the emergence of orientation selectivity in primary visual cortex (V1) of mammals lacking an orientation map (such as rodents and lagomorphs) are poorly understood. We present a computational model in which random connectivity gives rise to orientation selectivity that matches experimental observations. The model predicts that mouse V1 neurons should exhibit intricate receptive fields in the two-dimensional frequency domain, causing a shift in orientation preferences with spatial frequency. We find evidence for these features in mouse V1 using calcium imaging and intracellular whole-cell recordings.
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