期刊
CELL REPORTS
卷 9, 期 3, 页码 1007-1022出版社
CELL PRESS
DOI: 10.1016/j.celrep.2014.09.049
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资金
- NIH
- National Institute of Diabetes and Digestive and Kidney Diseases grants [R01 DK066556, R01 DK064261, R01 DK088220]
- National Heart, Blood and Lung Institute [5T32HL007360-34]
- American Heart Association [13POST14590008]
Adipose tissues have striking plasticity, highlighted by childhood and adult obesity. Using adipose lineage analyses, smooth muscle actin (SMA)-mural cell-fate mapping, and conditional PPAR gamma deletion to block adipocyte differentiation, we find two phases of adipocyte generation that emanate from two independent adipose progenitor compartments: developmental and adult. These two compartments are sequentially required for organ formation and maintenance. Although both developmental and adult progenitors are specified during the developmental period and express PPAR gamma, they have distinct microanatomical, functional, morphogenetic, and molecular profiles. Furthermore, the two compartments derive from different lineages; whereas adult adipose progenitors fate-map from an SMA+ mural lineage, developmental progenitors do not. Remarkably, the adult progenitor compartment appears to be specified earlier than the developmental cells and then enters the already developmentally formed adipose depots. Thus, two distinct cell compartments control adipose organ development and organ homeostasis, which may provide a discrete therapeutic target for childhood and adult obesity.
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