期刊
CELL REPORTS
卷 9, 期 3, 页码 1075-1088出版社
CELL PRESS
DOI: 10.1016/j.celrep.2014.09.045
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资金
- Wellcome Trust IITM Programme [092871/Z/10/Z]
- Wellcome Trust [WT091663MA]
- Medical Research Council
- NIHR Biomedical Research Centre (Oxford)
- Nuffield Department of Clinical Medicine (Oxford)
- James Martin School for the 21st Century (Oxford)
- NIH [NIAD U19AI 082630]
- Oxford Dominions Trust
- Medical Research Council [1890672] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10204] Funding Source: researchfish
- Wellcome Trust [092871/Z/10/Z] Funding Source: Wellcome Trust
The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant T (MAIT) cells. To understand whether different T cell subsets expressing CD161 have similar properties, we examined these populations in parallel using mass cytometry and mRNA microarray approaches. The analysis identified a conserved CD161++/MAIT cell transcriptional signature enriched in CD161+CD8+ T cells, which can be extended to CD161+ CD4+ and CD161+TCR gamma delta+ T cells. Furthermore, this led to the identification of a shared innate-like, TCR-independent response to interleukin (IL)-12 plus IL-18 by different CD161-expressing T cell populations. This response was independent of regulation by CD161, which acted as a costimulatory molecule in the context of T cell receptor stimulation. Expression of CD161 hence identifies a transcriptional and functional phenotype, shared across human T lymphocytes and independent of both T cell receptor (TCR) expression and cell lineage.
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