期刊
CELL REPORTS
卷 8, 期 4, 页码 923-932出版社
CELL PRESS
DOI: 10.1016/j.celrep.2014.07.013
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资金
- Israel Science Foundation-Morasha Foundation [1252/12]
- Israel Ministry of Science and Technology Infrastructure [3-9693]
- Rosetrees Trust
- Israel Cancer Research Fund (ICRF)
- Lady Davis Fellowship Trust
- Rosetrees Trust [M108-F1] Funding Source: researchfish
Males and females have a variety of sexually dimorphic traits, most of which result from hormonal differences. However, differences between male and female embryos initiate very early in development, before hormonal influence begins, suggesting the presence of genetically driven sexual dimorphisms. By comparing the gene expression profiles of male and X-inactivated female human pluripotent stem cells, we detected Y-chromosome-driven effects. We discovered that the sex-determining gene SRY is expressed in human male pluripotent stem cells and is induced by reprogramming. In addition, we detected more than 200 differentially expressed autosomal genes in male and female embryonic stem cells. Some of these genes are involved in steroid metabolism pathways and lead to sex-dependent differentiation in response to the estrogen precursor estrone. Thus, we propose that the presence of the Y chromosome and specifically SRY may drive sex-specific differences in the growth and differentiation of pluripotent stem cells.
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