期刊
CELL REPORTS
卷 3, 期 3, 页码 808-819出版社
CELL PRESS
DOI: 10.1016/j.celrep.2013.02.019
关键词
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类别
资金
- Innovative Areas (Comprehensive Brain Science Network)
- Asahi Glass Foundation
- Naito Foundation
- JSPS Research Fellowships for Young Scientists
- [19657005]
- [2337002]
- [20115003]
- Grants-in-Aid for Scientific Research [23590331, 23570007, 24650167, 20115003, 23370002, 25116713] Funding Source: KAKEN
The control of memory retention is important for proper responses to constantly changing environments, but the regulatory mechanisms underlying forgetting have not been fully elucidated. Our genetic analyses in C. elegans revealed that mutants of the TIR-1/JNK-1 pathway exhibited prolonged retention of olfactory adaptation and salt chemotaxis learning. In olfactory adaptation, conditioning induces attenuation of odor-evoked Ca2+ responses in olfactory neurons, and this attenuation is prolonged in the TIR-1/JNK-1-pathway mutant animals. We also found that a pair of neurons in which the pathway functions is required for the acceleration of forgetting, but not for sensation or adaptation, in wildtype animals. In addition, the neurosecretion from these cells is important for the acceleration of forgetting. Therefore, we propose that these neurons accelerate forgetting through the TIR-1/JNK-1 pathway by sending signals that directly or indirectly stimulate forgetting.
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