期刊
CELL REPORTS
卷 2, 期 1, 页码 111-123出版社
CELL PRESS
DOI: 10.1016/j.celrep.2012.06.003
关键词
-
类别
资金
- Department of Defense Prostate Cancer Research Program postdoctoral fellowship [W81XWH-10-1-0190]
- National Cancer Center postdoctoral fellowship
- [NCI 5P01CA013106-40]
- [NCI 2P30CA45508-24]
- [NIGMS 42694]
- [K99GM95713]
Genome-wide studies have identified thousands of long noncoding RNAs (lncRNAs) lacking protein-coding capacity. However, most lncRNAs are expressed at a very low level, and in most cases there is no genetic evidence to support their in vivo function. Malat1 (metastasis associated lung adenocarcinoma transcript 1) is among the most abundant and highly conserved lncRNAs, and it exhibits an uncommon 3'-end processing mechanism. In addition, its specific nuclear localization, developmental regulation, and dysregulation in cancer are suggestive of it having a critical biological function. We have characterized a Malat1 loss-of-function genetic model that indicates that Malat1 is not essential for mouse pre- and postnatal development. Furthermore, depletion of Malat1 does not affect global gene expression, splicing factor level and phosphorylation status, or alternative pre-mRNA splicing. However, among a small number of genes that were dysregulated in adult Malat1 knockout mice, many were Malat1 neighboring genes, thus indicating a potential cis-regulatory role of Malat1 gene transcription.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据