期刊
CELL REPORTS
卷 2, 期 4, 页码 914-926出版社
CELL PRESS
DOI: 10.1016/j.celrep.2012.09.005
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资金
- Arthritis Research UK
- Medical Research Council New Investigators Research Grant [G070010881726]
- MRC [G0700108] Funding Source: UKRI
- Medical Research Council [G0700108] Funding Source: researchfish
- Versus Arthritis [20003] Funding Source: researchfish
Endogenous molecules generated upon pathogen invasion or tissue damage serve as danger signals that activate host defense; however, their precise immunological role remains unclear. Tenascin-C is an extracellular matrix glycoprotein that is specifically induced upon injury and infection. Here, we show that its expression is required to generate an effective immune response to bacterial lipopolysaccharide (LPS) during experimental sepsis in vivo. Tenascin-C enables macrophage translation of proinflammatory cytokines upon LPS activation of toll-like receptor 4 (TLR4) and suppresses the synthesis of anti-inflammatory cytokines. It mediates posttranscriptional control of a specific subset of inflammatory mediators via induction of the micro-RNA miR-155. Thus, tenascin-C plays a key role in regulating the inflammatory axis during pathogenic activation of TLR signaling.
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