期刊
CELL REPORTS
卷 2, 期 5, 页码 1151-1158出版社
CELL PRESS
DOI: 10.1016/j.celrep.2012.10.013
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类别
资金
- intramural research program of the NEI
- National Center for Complementary and Alternative Medicine
- National Heart Lung and Blood Institute
- Foundation Fighting Blindness
- Macular Degeneration Center Research Fund of the CEI
- Research to Prevent Blindness
- National Health and Medical Research Council Centre for Clinical Research Excellence [529923]
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis.
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