期刊
CELL REPORTS
卷 2, 期 4, 页码 738-747出版社
CELL PRESS
DOI: 10.1016/j.celrep.2012.08.024
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资金
- Israel Science Foundation [ISF 843/11]
- Abisch-Frenkel Foundation
- GIF, the German-Israeli Foundation for Scientific Research and Development [2267-2166.9/2010]
- ER Architecture grant [ERC-StG-2010 260395]
The division of the S. cerevisiae budding yeast, which produces one mother cell and one daughter cell, is asymmetric with respect to aging. Remarkably, the asymmetry of yeast aging coincides with asymmetric inheritance of damaged and aggregated proteins by the mother cell. Here, we show that misfolded proteins are retained in the mother cell by being sequestered in juxtanuclear quality control compartment (JUNQ) and insoluble protein deposit (IPOD) inclusions, which are attached to organelles. Upon exposure to stress, misfolded proteins accumulate in stress foci that must be disaggregated by Hsp104 in order to be degraded or processed to JUNQ and IPOD. Cells that fail to deliver aggregates to an inclusion pass on aggregates to subsequent generations.
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