期刊
CELL AND BIOSCIENCE
卷 3, 期 -, 页码 -出版社
BMC
DOI: 10.1186/2045-3701-3-41
关键词
Adult stem cell; Germline stem cell; Intestinal stem cell; Hair follicle stem cell; Epigenetics; Cancer; Cancer stem cell
资金
- National Institutes of Health [National Cancer Institute] [F31CA165781]
- National Institutes of Health [National Institute of General Medical Sciences] [T32 GM007231]
- National Institutes of Health [National Institute of Child Health and Human Development] [R01HD065816]
- David and Lucile Packard Foundation
- Johns Hopkins University
Adult stem cells maintain tissue homeostasis by their ability to both self-renew and differentiate to distinct cell types. Multiple signaling pathways have been shown to play essential roles as extrinsic cues in maintaining adult stem cell identity and activity. Recent studies also show dynamic regulation by epigenetic mechanisms as intrinsic factors in multiple adult stem cell lineages. Emerging evidence demonstrates intimate crosstalk between these two mechanisms. Misregulation of adult stem cell activity could lead to tumorigenesis, and it has been proposed that cancer stem cells may be responsible for tumor growth and metastasis. However, it is unclear whether cancer stem cells share commonalities with normal adult stem cells. In this review, we will focus on recent discoveries of epigenetic regulation in multiple adult stem cell lineages. We will also discuss how epigenetic mechanisms regulate cancer stem cell activity and probe the common and different features between cancer stem cells and normal adult stem cells.
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