期刊
FRONTIERS IN PHARMACOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2015.00152
关键词
voltage-gated sodium channel; cell excitability; cancer; sodium; invasion
资金
- Ministere de la Recherche et des Technologies
- Inserm
- Ligue Nationale Contre le Cancer
- Region Centre (grant NaVMetarget and LIPIDS project of ARD-Biomedicaments)
- Association CANCEN
Voltage-gated sodium channels (Na-v) are molecular characteristics of excitable cells. Their activation, triggered by membrane depolarization, generates transient sodium currents that initiate action potentials in neurons and muscle cells. Sodium currents were discovered by Hodgkin and Huxley using the voltage clamp technique and reported in their landmark series of papers in 1952. It was only in the 1980's that sodium channel proteins from excitable membranes were molecularly characterized by Catterall and his collaborators. Non-excitable cells can also express Nay channels in physiological conditions as well as in pathological conditions. These Nay channels can sustain biological roles that are not related to the generation of action potentials. Interestingly, it is likely that the abnormal expression of Nay in pathological tissues can reflect the re-expression of a fetal phenotype. This is especially true in epithelial cancer cells for which these channels have been identified and sodium currents recorded, while it was not the case for cells from the cognate normal tissues. In cancers, the functional activity of Nay appeared to be involved in regulating the proliferative, migrative, and invasive properties of cells. This review is aimed at addressing the non-excitable roles of Nay channels with a specific emphasis in the regulation of cancer cell biology.
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