期刊
ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL
卷 2010, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2010/453642
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资金
- Deutsche Forschungsgemeinschaft [SFB 579]
- National Institutes of Health [GM070663]
- Department of Energy [DE-FG0202-91ER200042]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM070663] Funding Source: NIH RePORTER
Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation. Among the archaea, they are also the only known group synthesizing proteins containing selenocysteine or pyrrolysine. All but one of the known archaeal pyrrolysine-containing and all but two of the confirmed archaeal selenocysteine-containing protein are involved in methanogenesis. Synthesis of these proteins proceeds through suppression of translational stop codons but otherwise the two systems are fundamentally different. This paper highlights these differences and summarizes the recent developments in selenocysteine-and pyrrolysine-related research on archaea and aims to put this knowledge into the context of their unique energy metabolism.
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