期刊
FEBS OPEN BIO
卷 5, 期 -, 页码 733-740出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.fob.2015.08.010
关键词
MeCP2; miRNA; Neuropathic pain; BDNF
资金
- Commonwealth Universal Research Enhancement (CURE)
- Pennsylvania Department of Health
- Rita Allen Foundation
Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated microRNAs are predicted to target Mecp2. MECP2 mutations cause Rett syndrome and these patients report decreased pain perception. We confirmed MeCP2 upregulation in DRG following nerve injury and repression of MeCP2 by miRNAs in vitro. MeCP2 regulates brain-derived neurotrophic factor (BDNF) and downregulation of MeCP2 by microRNAs decreased Bdnf in vitro. MeCP2 T158A mice exhibited reduced mechanical sensitivity and Mecp2-null and MeCP2 T158A mice have decreased Bdnf in DRG. MeCP2-mediated regulation of Bdnf in the DRG could contribute to altered pain sensitivity. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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